How Long to Cook Pork Tenderloin in Oven at 400?

Hey there, cooking enthusiasts! Are you searching for the perfect recipe for pork tenderloin? Look no further, as we have got you covered with the best tips and tricks for cooking pork tenderloin in the oven at 400 degrees Fahrenheit. In this article, we will guide you through the cooking process step by step, so you can achieve a tender and flavorful pork tenderloin every time. So, let’s get started!

Preparing the Pork Tenderloin

Before we jump into the cooking process, let’s talk about the preparation of the pork tenderloin. The first step is to remove the silver skin from the pork tenderloin. The silver skin is a thin, tough membrane that runs along the surface of the tenderloin. Using a sharp knife, carefully cut the silver skin away from the meat in a slow, back and forth motion. Once you have removed the silver skin, it’s time to season the pork tenderloin.

Seasoning the Pork Tenderloin

To add flavor to the pork tenderloin, we recommend seasoning it with a blend of herbs and spices. You can use a pre-made seasoning blend or make your own by combining salt, pepper, garlic powder, onion powder, and dried herbs like rosemary or thyme. Rub the seasoning blend all over the pork tenderloin, making sure to coat it evenly. You can also add a tablespoon of olive oil to help the seasoning adhere to the meat.

Cooking the Pork Tenderloin

Now that your pork tenderloin is prepped and seasoned, it’s time to cook it in the oven. Preheat your oven to 400 degrees Fahrenheit. Place the pork tenderloin in a roasting pan or on a baking sheet lined with parchment paper. Cook the pork tenderloin for 20-25 minutes, or until the internal temperature of the meat reaches 145 degrees Fahrenheit.

Resting the Pork Tenderloin

After taking the pork tenderloin out of the oven, it’s essential to let it rest for about ten minutes before slicing. This resting time allows the juices to redistribute throughout the meat, making it juicier and more tender.

Serving the Pork Tenderloin

Once the pork tenderloin has rested, it’s time to serve it up! You can slice the meat into medallions or keep it whole and slice it at the table. Pair it with your favorite sides, such as roasted vegetables or mashed potatoes, and enjoy!

Tips for Cooking Pork Tenderloin

– Always remove the silver skin from the pork tenderloin before cooking. This will make the meat more tender and flavorful.- Season the pork tenderloin generously with herbs and spices to add flavor.- Use a meat thermometer to ensure that the internal temperature of the pork tenderloin reaches 145 degrees Fahrenheit.- Let the pork tenderloin rest for ten minutes before slicing to allow the juices to redistribute throughout the meat.


Cooking a pork tenderloin in the oven at 400 degrees Fahrenheit is a straightforward process. By following our step-by-step guide and tips, you can achieve a tender and flavorful pork tenderloin every time. Remember to remove the silver skin, season generously, use a meat thermometer, and let the meat rest before slicing. With these tips, you’ll be serving up delicious pork tenderloin in no time!Thank you for reading, and we’ll see you soon with more exciting articles!